Phenotypes Associated with This Genotype

Genotype
MGI:5476988

• Allelic Composition: Nudt1^tm1Tts/Nudt1^tm1Tts; Ogg1^tm1Yun/Ogg1^tm1Yun
• Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

neurodegeneration ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:193978 )

• 3-NP treated mice exhibit increased motor impairment (neurological score based on: general slowness of displacement resulting from mild hindlimb impairment;, incoordination and marked gait abnormality; hindlimb paralysis; incapacity to move resulting from forelimb and hindlimb impairment) compared with wild-type mice

decreased vertical activity ( J:193978 )

• in 3-NP-treated mice

decreased locomotor activity ( J:193978 )

• 3-NP-treated mice travel less distance in an open-field test compared with wild-type mice that is more severe than in Ogg1^tm1Skmi homozygotes

• 3-NP-treated mice are hypoactive in home cages compared with wild-type mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

cellular

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

• 3-NP treated mice exhibit an accumulation of 8-oxoG that results in the accumulation of single strand breaks in mitochondrial DNA of striatal medium spiny neurons and nuclear DNA of striatal microglia compared with wild-type mice

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

• 3-NP treated mice exhibit an accumulation of 8-oxoG that results in the accumulation of single strand breaks in mitochondrial DNA of striatal medium spiny neurons and nuclear DNA of striatal microglia compared with wild-type mice

immune system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

hematopoietic system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum