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Phenotypes Associated with This Genotype
Genotype
MGI:5467984
Allelic
Composition
Atxn2tm2.1Aub/Atxn2tm2.1Aub
Genetic
Background
B6.129S2-Atxn2tm2.1Aub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn2tm2.1Aub mutation (1 available); any Atxn2 mutation (87 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal grip strength, horizontal/vertical activity, total distance, movement time, number of movements, number of stereotypy counts, margin/center distance nor margin/center time
• 1.2-fold increase in latency to fall from a rotarod at 6 weeks
• decreased latency to fall from a rotarod at 18 months
• however, there is no difference at 3, 6 and 12 months

growth/size/body
• from P20 onward

nervous system
• Atxn2 and Pabpc1 protein aggregates in Purkinje cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spinocerebellar ataxia type 2 DOID:0050955 OMIM:183090
J:188118


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory