Phenotypes Associated with This Genotype

Genotype
MGI:5466412

• Allelic Composition: Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Open eyelids at birth in Limk2^{Gt(OST80053)Lex}/Limk2^{Gt(OST80053)Lex} mice

vision/eye

retina neovascularization ( J:192231 )

• in the cornea

increased incidence of corneal inflammation ( J:192231 )

• in exposed area of the cornea in young mice

abnormal cornea morphology ( J:192231 )

• young mice exhibit keratinization, inflammation and edema in the exposed areas of the corneal unlike wild-type mice

• some mice exhibit thick serocellular crust on the corneal surface unlike wild-type mice

• however, ocular anatomy prior to birth is normal

abnormal cornea epithelium morphology ( J:192231 )

• keratinization on the palpebral epidermis

decreased eye anterior chamber depth ( J:192231 )

• shallow anterior chamber

abnormal eyelid development ( J:192231 )

• epithelial sheet migration is inhibited and the leading keratinocytes fail to nucleate filamentous actin and keratinocytes remain immobile during eyelid development

failure of eyelid fusion ( J:192231 )

• eyes are open at E15.5 and E18.5

eyelids open at birth ( J:192231 )

immune system

increased incidence of corneal inflammation ( J:192231 )

• in exposed area of the cornea in young mice

cardiovascular system

retina neovascularization ( J:192231 )

• in the cornea