Phenotypes Associated with This Genotype

Genotype
MGI:5461653

• Allelic Composition: Dp(7Herc2-Mkrn3)1Taku/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased adrenaline level ( J:190050 )

• mice with a maternally inherited duplication (matDp/+) exhibit increased epinephrine levels in the striatum and frontal cortex

• mice with a paternally inherited duplication (patDP/+) exhibit increased epinephrine levels in the cerebellum and cortex

increased dopamine level ( J:190050 )

• both patDp/+ and matDp/+ mice exhibit increased dopamine levels in the striatum and the midbrain and patDp/+ mice also have increased levels in the frontal cortex

• matDp/+ mice exhibit increased DOPAC levels in the striatum while patDp/+ mice exhibit increased levels in the cerebellum, midbrain, and frontal cortex

increased noradrenaline level ( J:190050 )

• matDp/+ mice exhibit increased norepinephrine within the striatal, hippocampal and cerebellar regions

decreased serotonin level ( J:190050 )

• mice with a paternally (patDp/+), but not maternally (matDp/+), inherited duplication exhibit decreased 5HT (serotonin) levels in the hippocampus and midbrain regions

• patDp/+ mice exhibit a decrease in HIAA, a major metabolite of 5HT, in the cortical and striatal regions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:190050