Phenotypes Associated with This Genotype

Genotype
MGI:5451076

• Allelic Composition: Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10069A-G10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteocyte apoptosis ( J:167585 )

• osteocyte apoptosis is reduced compared to in wild-type mice

increased bone mineral density of lumbar vertebrae ( J:167585 )

• increased bone mineral density of lumbar vertebrae at 4 and 6 months of age

increased bone mineral density of femur ( J:167585 )

• increased bone mineral density of femur at 4 and 6 months of age

abnormal compact bone morphology ( J:167585 )

• tibial cortical bone area, bone thickness, and polar moment of inertia are increased compared to in wild-type mice

increased compact bone area ( J:167585 )

increased compact bone thickness ( J:167585 )

abnormal trabecular bone morphology ( J:167585 )

• tibial trabecular bone fraction, thickness, and bone density are increased compared to in wild-type mice

increased trabecular bone thickness ( J:167585 )

increased bone mass ( J:167585 )

• in the tibia

cellular

decreased osteocyte apoptosis ( J:167585 )

• osteocyte apoptosis is reduced compared to in wild-type mice