Phenotypes Associated with This Genotype

Genotype
MGI:5441982

• Allelic Composition: Rr20^tm1.1Vlcg/Rr20^tm1.1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Higher bone mass in Rr20^tm1.1Vlcg/Rr20^tm1.1Vlcg and Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} mice

skeleton

skeleton phenotype ( J:188586 )

N • mice exhibit normal osteoclast activity

abnormal osteoblast morphology ( J:188586 )

• at 6 months, mice exhibit an increase in osteoblast surface in the trabecular compartment compared with wild-type mice

abnormal trabecular bone morphology ( J:188586 )

• lower trabecular separation, increased osteoblast surface and reduced structure model index at 6 months

increased trabecular bone volume ( J:188586 )

• at 6 months

increased bone trabecula number ( J:188586 )

• at 6 months

increased trabecular bone connectivity density ( J:188586 )

• at 6 months

increased bone mass ( J:188586 )

• 2-fold

abnormal bone ossification ( J:188586 )

• 2-fold increase in bone formation at the distal femur

abnormal bone mineralization ( J:188586 )

• increased mineral apposition rate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
SOST-related sclerosing bone dysplasia		DOID:0080036	OMIM:239100	J:188586