Phenotypes Associated with This Genotype

Genotype
MGI:5438572

• Allelic Composition: Nrarp^tm1Grid/Nrarp^tm1Grid
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

rib fusion ( J:187871 )

• at low penetrance

• Background Sensitivity: less severe than on a pure 129 background

vertebral fusion ( J:187871 )

• in the thoracic, lumbar, sacral and caudal regions but not cervical

• fusion of adjacent vertebral bodies and pedicles

• Background Sensitivity: mice on a mixed 129 and C57BL/6J background exhibit less penetrance and expressivity of vertebral abnormalities compared to on a pure 129 background

• Background Sensitivity: additional backcrossing to C67BL/6J rescues all but the defects in the ninth and tenth thoracic vertebra

caudal vertebral fusion ( J:187871 )

thoracic vertebral fusion ( J:187871 )

lumbar vertebral fusion ( J:187871 )

sacral vertebral fusion ( J:187871 )

fusion of vertebral bodies ( J:187871 )

limbs/digits/tail

caudal vertebral fusion ( J:187871 )