Phenotypes Associated with This Genotype

Genotype
MGI:5437482

• Allelic Composition: Yipf6^M1Btlr/Y
• Genetic Background: C57BL/6J-Yipf6^M1Btlr/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mice hemizygous or homozygous for Yipf6^M1Btlr show increased susceptibility to induced colitis

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:187584 )

♂ • after administration with DSS

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:187584 )

♂ • reduced in number, contain less stainable material and oddly shaped

abnormal pancreatic acinar cell morphology ( J:187584 )

♂ • acinar cells have swollen ER

abnormal colon morphology ( J:187584 )

♂ • decreased colon length in 16 month old mice with numerous cellular defects of the lamina propria and epithelium in the small intestine and colon

♂ • reduced mucin content

abnormal small intestine morphology ( J:187584 )

♂ • numerous cellular defects of the lamina propria and epithelium in the small intestine and colon in 16 month old mice

abnormal Paneth cell morphology ( J:187584 )

♂ • reduced in number, contain less stainable material and oddly shaped

decreased Paneth cell number ( J:187584 )

♂

colitis ( J:187584 )

♂ • 16 month old mice exhibit shortening of the colon, cellular defects of the lamina propria and epithelium in the small intestine and colon, neutrophilic and lymphocytic infiltrates in the lamina propria of the small intestine, villus fusion, thickening submucosa and crypt abcesses unlike wild-type mice

increased susceptibility to induced colitis ( J:187584 )

♂ • mice treated with DDS exhibit increased weight loss, dramatic leukocyte recruitment in the colon, crypt loss in the colon and mortality compared with wild-type mice

♂ • hypersensitivity to DSS is not dependent on hematopoietic cells

growth/size/body

increased susceptibility to weight loss ( J:187584 )

♂ • after administration with DSS

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:187584 )

♂ • after administration with DSS

immune system

colitis ( J:187584 )

♂ • 16 month old mice exhibit shortening of the colon, cellular defects of the lamina propria and epithelium in the small intestine and colon, neutrophilic and lymphocytic infiltrates in the lamina propria of the small intestine, villus fusion, thickening submucosa and crypt abcesses unlike wild-type mice

increased susceptibility to induced colitis ( J:187584 )

♂ • mice treated with DDS exhibit increased weight loss, dramatic leukocyte recruitment in the colon, crypt loss in the colon and mortality compared with wild-type mice

♂ • hypersensitivity to DSS is not dependent on hematopoietic cells

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:187584 )

♂ • acinar cells have swollen ER

abnormal Paneth cell morphology ( J:187584 )

♂ • reduced in number, contain less stainable material and oddly shaped

decreased Paneth cell number ( J:187584 )

♂

cellular

abnormal intestinal goblet cell morphology ( J:187584 )

♂ • reduced in number, contain less stainable material and oddly shaped