Phenotypes Associated with This Genotype

Genotype
MGI:5432258

• Allelic Composition: Tg(MMTV-rtTA)1Lach/0; Tg(tetO-IGF1R)1Ramo/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:121069 )

• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days

• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands

• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma

• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma

increased mammary adenocarcinoma incidence ( J:121069 )

• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma

endocrine/exocrine glands

abnormal mammary gland development ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development

abnormal branching of the mammary ductal tree ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad

abnormal mammary gland epithelium morphology ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

increased mammary gland tumor incidence ( J:121069 )

• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days

• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands

• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma

• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma

increased mammary adenocarcinoma incidence ( J:121069 )

• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma

mammary gland hyperplasia ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

integument

abnormal mammary gland development ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit impaired mammary ductal development

abnormal branching of the mammary ductal tree ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age show a delay in ductal elongation and in some cases the duct remains behind in the lymph node compared to controls in which ductal structure almost completely fills the mammary fat pad

abnormal mammary gland epithelium morphology ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

increased mammary gland tumor incidence ( J:121069 )

• mutants maintained on doxycycline for an extended period of time develop mammary tumors with an average latency of 78 days

• doxycycline-treated mutants typically develop one or two tumors in the first or second/third mammary glands with hyperplastic nodules in the other mammary glands

• small mammary lesions are primarily composed of solid sheets of tumor cells with sparse stroma

• larger tumors are more heterogeneous in appearance, with tumors displaying features of adenosquamous carcinoma, adenomyoepithelioloma, and glandular adenocarcinoma

increased mammary adenocarcinoma incidence ( J:121069 )

• larger tumors display features of adenosquamous carcinoma and glandular adenocarcinoma

mammary gland hyperplasia ( J:121069 )

♀ • 55 day old mutants induced with doxycycline beginning at 21 days of age exhibit mammary epithelial hyperplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:121069