Phenotypes Associated with This Genotype

Genotype
MGI:5428686

• Allelic Composition: Tg(H2-K1-HLA-A*)28Mpla/0
• Genetic Background: B10.Cg-Tg(H2-K1-HLA-A*)28Mpla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

eye inflammation ( J:67871 )

• retinal vasculitis and perivasculitis in some mice aged 12 months or more

• inflammation is largely confined to the posterior segment of the eye

• the vitreous and the optic disk are infiltrated by inflammatory cells and this is frequently associated with inflammation in the arachnoid of the optic nerve and in the choroid

choroid inflammation ( J:67871 )

abnormal eye pigmentation ( J:67871 )

• cells containing pigment are present in the subretinal space forming clusters located under retinal folds

abnormal retina morphology ( J:67871 )

• some mice aged 12 months or more develop spontaneous, typically bilateral retinopathy

abnormal retina pigment epithelium morphology ( J:67871 )

• thickened

retina detachment ( J:67871 )

• local detachments are frequently seen in mice aged 12 months or more

retina fold ( J:67871 )

immune system

eye inflammation ( J:67871 )

• retinal vasculitis and perivasculitis in some mice aged 12 months or more

• inflammation is largely confined to the posterior segment of the eye

• the vitreous and the optic disk are infiltrated by inflammatory cells and this is frequently associated with inflammation in the arachnoid of the optic nerve and in the choroid

choroid inflammation ( J:67871 )

pigmentation

abnormal eye pigmentation ( J:67871 )

• cells containing pigment are present in the subretinal space forming clusters located under retinal folds

abnormal retina pigment epithelium morphology ( J:67871 )

• thickened

cardiovascular system

vascular inflammation ( J:67871 )

• retinal vasculitis and perivasculitis in some mice aged 12 months or more

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
birdshot chorioretinopathy		DOID:0111079	OMIM:605808	J:67871