Analysis Tools
limbs/digits/tail
|
• expression analysis indicates proximal patterning defects in the hindlimb buds
|
|
• variable severity of hindlimb digit loss
• almost half of mice display hindlimbs with only 3 digits
• less severely affected mice develop 4 hindlimb digits, lacking the posterior digit 5
|
|
• only a single zeugopodal element, likely corresponding to the tibia, is present in most mice with 1 - 3 digits on the hindlimb
• mice with 4 digits on the hindlimb show more variability in zeugopodal defects
|
|
• in severely affected mice
|
embryo
|
• expression analysis indicates proximal patterning defects in the hindlimb buds
|
skeleton
|
• patterning failure
|
absent pubis
(
J:184018
)
|
• patterning failure
|
