Phenotypes Associated with This Genotype

Genotype
MGI:5318687

• Allelic Composition: Tg(CMV-IGL@AL080)55Dcs/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:179082 )

• as mutants age, about 20% develop a neurologic phenotype characterized by a gait disturbance and limb clenching when picked up by the tail

abnormal gait ( J:179082 )

• as mutants age, about 20% develop a neurologic phenotype characterized by a gait disturbance and limb clenching when picked up by the tail

decreased vertical activity ( J:179082 )

• while spontaneous activity is normal under normal feeding conditions and under fasting conditions during the day, mutants show less spontaneous motion, particularly with regards to rearing, under fasting conditions at night

decreased aerobic running capacity ( J:179082 )

• older mutants (9 months of age) but not younger ones (3 months of age) exhibit impairment in ability to run for extended times on an inclined treadmill and perform less work than controls

digestive/alimentary system

abnormal stomach epithelium morphology ( J:179082 )

• stomach epithelium is often dysplastic

• stomach epithelium often forms polyps and has dilated glands filled with Congophilic material

gastric polyps ( J:179082 )

• stomach epithelium often forms polyps

homeostasis/metabolism

decreased aerobic running capacity ( J:179082 )

• older mutants (9 months of age) but not younger ones (3 months of age) exhibit impairment in ability to run for extended times on an inclined treadmill and perform less work than controls

amyloidosis ( J:179082 )

• mutants develop amyloid deposits in the stomach (in the lumen of the gastric glands) with age, with 26% having deposits by 6 months of age and 83% having deposits by 24-30 months of age

• however, mutants do not exhibit amyloid deposits in the heart or kidneys

• treatment with doxycycline inhibits amyloid fibril formation

nervous system

axonal dystrophy ( J:179082 )

• mutants exhibit neurons with dystrophic axons in the spinal cord and medulla

cardiovascular system

cardiovascular system phenotype ( J:179082 )

N • mutants exhibit normal cardiac function, including normal ejection fraction, fractional shortening, heart rate, and thickness of the interventricular septum and left ventricle size

renal/urinary system

renal/urinary system phenotype ( J:179082 )

N • mutants exhibit normal total urinary protein secretion and blood urea nitrogen levels, indicating normal renal function

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyloidosis		DOID:9120		J:179082