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Phenotypes Associated with This Genotype
Genotype
MGI:5315853
cn40
Allelic
Composition		 Huwe1tm1Wgu/Y
Tg(Ins2-cre)23Herr/0
Trp53tm1Thl/Trp53tm1Thl
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Wgu mutation (0 available); any Huwe1 mutation (62 available)
Tg(Ins2-cre)23Herr mutation (1 available)
Trp53tm1Thl mutation (0 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:182446 )
N
• mice survive longer than Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:182446 )
N
• diabetic symptoms (serum glucose and insulin levels and glucose intolerance) observed in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice are improved
hyperglycemia ( J:182446 )
• in fasting mice at 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice
• in fed mice at 3, 6 and 9 months but not as severe as in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:182446 )
N
• islet organization is improved compared to in Huwe1tm1Wgu/Y Tg(Ins2-cre)23Herr mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory