Phenotypes Associated with This Genotype

Genotype
MGI:5313304

hm1

• Allelic Composition: Batf3^tm1Kmm/Batf3^tm1Kmm
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:181366 )

N • homozygotes retain an enhanced antibody response to anti-Clec9a coupled antigen

abnormal cytotoxic T cell physiology ( J:181366 )

• reduced cytotoxic T cell response to anti-Clec9a coupled antigen

abnormal dendritic cell antigen presentation ( J:362930 )

• mice immunized with OVA-beads + poly(I:C) do not mount a strong OVA-specific CD8+ T cell response

• mice immunized with ultraviolet-irradiated, OVA-coated NIH-3T3 cells (H-2^q) + poly(I:C) show a reduced OVA-specific CD8+ T cell response

hematopoietic system

abnormal cytotoxic T cell physiology ( J:181366 )

• reduced cytotoxic T cell response to anti-Clec9a coupled antigen