Phenotypes Associated with This Genotype

Genotype
MGI:5303086

cx4

• Allelic Composition: Abcc8^tm1Jbry/Abcc8^tm1Jbry; Sstr5^tm1Fcb/Sstr5^tm1Fcb
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal insulin secretion ( J:179577 )

• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls

decreased insulin secretion ( J:179577 )

• insulin levels near zero

homeostasis/metabolism

abnormal insulin secretion ( J:179577 )

• insulin levels fail to rise 30 minutes after glucose injection as they do in wild type controls

decreased insulin secretion ( J:179577 )

• insulin levels near zero

decreased circulating glucose level ( J:179577 )

• significantly lower glucose levels after 16 hours of fasting compared to wild type controls

• basal levels are like wild type controls

increased circulating glucose level ( J:179577 )

• very significantly elevated glucose at both 30 and 60 minutes after glucose injection