Phenotypes Associated with This Genotype

Genotype
MGI:5302408

• Allelic Composition: Il20ra^tm1.1Misc/Il20ra^tm1.1Misc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Il20ra^tm1.1Misc/Il20ra^tm1.1Misc mice are protected from ovariectomy-induced bone loss

skeleton

abnormal bone structure ( J:177783 )

• ovariectomized mice are protected from induced bone loss (reflected by deterioration of bone volume, trabecular bone thickness, trabecular number, and trabecular separation) compared with wild-type mice

abnormal osteoclast differentiation ( J:177783 )

• basal and IL20-induced osteoclast differentiation are impaired compared to in wild-type mice

increased bone mineral density ( J:177783 )

• in the tibia

increased bone volume ( J:177783 )

increased trabecular bone thickness ( J:177783 )

decreased bone resorption ( J:177783 )

• in ovariectomized mice

immune system

abnormal osteoclast differentiation ( J:177783 )

• basal and IL20-induced osteoclast differentiation are impaired compared to in wild-type mice

cellular

abnormal osteoclast differentiation ( J:177783 )

• basal and IL20-induced osteoclast differentiation are impaired compared to in wild-type mice

hematopoietic system

abnormal osteoclast differentiation ( J:177783 )

• basal and IL20-induced osteoclast differentiation are impaired compared to in wild-type mice