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Phenotypes Associated with This Genotype
Genotype
MGI:5298865
hm2
Allelic
Composition
Esr2tm1Mma/Esr2tm1Mma
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr2tm1Mma mutation (0 available); any Esr2 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in an elevated plus maze, female mice exhibit fewer time in open arms and head dips compared with wild-type mice
• however, male mice exhibit normal anxiety-related behavior
• in female mice in an open field
• in female mice in an open field
• in female mice in an open field
• in ovariectomized female mice during the interphase and early tonic phase II of the formalin test but not during acute and late tonic phases

nervous system
• female mice exhibit reduced threshold for the induction of synaptic plasticity in the basolateral amygdala compared with wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/24/2026
MGI 6.24
The Jackson Laboratory