About   Help   FAQ
Phenotypes Associated with This Genotype
involves: 129P2/OlaHsd * 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm1.2Cidz mutation (0 available); any Fmr1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants show a lower AMPA to NMDA glutamate receptor ratio in hippocampal CA1 pyramidal neurons at 2 weeks of age, but not at 6-7 weeks of age
• mutants show a lower AMPA to NMDA current ratio in hippocampal CA1 neurons at 2 weeks of age, but not at 6-7 weeks of age, indicating that glutamatergic neuerotransmission at synapses of hippocampal CA1 pyramidal neurons is altered during early postnatal development but not in adulthood
• induction of NMDA receptor-dependent long-term potentiation following a low-frequency pairing protocol, but not theta-burst pairing protocol, is increased at 2 weeks of age but not in adulthood
• however, presynaptic paired-pulse potentiation in the hippocampal CA1 neurons and intrinsic postsynaptic excitability are unchanged in mutants and no differences in short- and long-term depression are seen
• miniature currents are altered in mutants; AMPA mEPSCs are reduced in amplitude but not in frequency while NMDA mEPSCs are increased in amplitude

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fragile X syndrome DOID:14261 OMIM:300624

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory