Analysis Tools
mortality/aging
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• mice die between E9.5 and E12.5
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cardiovascular system
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• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice
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• at E10.5, mice exhibit vascular defects with fusion of large diameter vessels and absence of patterning compared with wild-type mice
• however, pericyte coverage is normal
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• at E 9.5, mice exhibit heart defects and loss of heart trabeculation unlike wild-type mice
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embryo
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• at E10.5
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nervous system
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• at E10.5, mice exhibit an increase in vasculature in the hindbrain compared with wild-type mice
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growth/size/body
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• at E10.5
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