Phenotypes Associated with This Genotype

Genotype
MGI:5052120

• Allelic Composition: Tg(Eno2-PSEN2*)1480Ykk/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:76934 )

• impaired performance in a water maze test at 12 months of age compared to aged matched controls

impaired swimming ( J:76934 )

• slight reduction in swimming speed

nervous system

amyloid beta deposits ( J:76934 )

• increase in amyloid beta 42 levels compared to age matched controls

homeostasis/metabolism

amyloid beta deposits ( J:76934 )

• increase in amyloid beta 42 levels compared to age matched controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:76934