Phenotypes Associated with This Genotype

Genotype
MGI:5008644

• Allelic Composition: Tg(Plp1-SNCA)1Haa/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:96778 )

• 46% of 3-NP-treated mice die unlike similarly treated wild-type mice

nervous system

microgliosis ( J:96778 )

• in 3-NP-treated mice

abnormal striatum morphology ( J:96778 )

• 3-NP-treated mice exhibit a decreased in striatal volume compared with similarly treated wild-type mice

decreased Purkinje cell number ( J:96778 )

• in 3-NP-treated mice

small cerebellum ( J:96778 )

• decreased cerebellar volume in 3-NP-treated mice

astrocytosis ( J:96778 )

• in 3-NP-treated mice

loss of dopaminergic neurons ( J:96778 )

• prior to and exacerbated by 3-NP treatment

neuron degeneration ( J:96778 )

• 3-NP-treated mice exhibit increased striatal neuron loss compared with similarly treated wild-type mice

• 3-NP-treated mice exhibit neuronal loss in the cerebellar, pontine, and inferior olive compared with similarly treated wild-type mice

behavior/neurological

impaired coordination ( J:96778 )

• in open field, pole, and stride length tests, all mice treated with 3-NP exhibit motor impairment compared with less than half of similarly treated wild-type mice

short stride length ( J:96778 )

• in 3-NP-treated mice

decreased vertical activity ( J:96778 )

• in 3-NP-treated mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:96778 )

• 46% of 3-NP-treated mice die unlike similarly treated wild-type mice

immune system

microgliosis ( J:96778 )

• in 3-NP-treated mice

hematopoietic system

microgliosis ( J:96778 )

• in 3-NP-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple system atrophy		DOID:4752		J:96778