Phenotypes Associated with This Genotype

Genotype
MGI:5000486

• Allelic Composition: Stab1^tm1.1Cger/Stab1^tm1.1Cger; Stab2^tm1.1Cger/Stab2^tm1.1Cger
• Genetic Background: C.129S2-Stab2^tm1.1Cger Stab1^tm1.1Cger

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mesangial expansion and glomerular fibrosis in Stab1^tm1.1Cger/Stab1^tm1.1CgerStab2^tm1.1Cger/Stab2^tm1.1Cger mice

mortality/aging

premature death ( J:171818 )

• mean survival is 269 days

cardiovascular system

pulmonary vascular congestion ( J:171818 )

• in some mice

dilated cardiomyopathy ( J:171818 )

• incipient to overt with or without heart failure and pulmonary congestion

congestive heart failure ( J:171818 )

• in some mice

renal/urinary system

albuminuria ( J:171818 )

• highly elevated at 3 and 6 months

renal glomerulus fibrosis ( J:171818 )

• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice

• however, fibrosis is rescued by transplanting kidney into wild-type mice

abnormal kidney physiology ( J:171818 )

• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system

liver fibrosis ( J:171818 )

• perisinusoidal

abnormal liver physiology ( J:171818 )

• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

respiratory system

pulmonary vascular congestion ( J:171818 )

• in some mice

homeostasis/metabolism

albuminuria ( J:171818 )

• highly elevated at 3 and 6 months

muscle

dilated cardiomyopathy ( J:171818 )

• incipient to overt with or without heart failure and pulmonary congestion