Phenotypes Associated with This Genotype

Genotype
MGI:5000258

• Allelic Composition: Stx1a^tm1Tfuj/Stx1a^tm1Tfuj
• Genetic Background: B6.Cg-Stx1a^tm1Tfuj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal latent inhibition of conditioning behavior ( J:171786 )

• the inhibition ratio is significantly attenuated compared to wild-type controls

• treatment with fluoxetine restores latent inhibition

abnormal response to novel object ( J:171786 )

• when presented with a novel and a familiar object exploring ration for the novel object is significantly lower than in wild-type mice

increased startle reflex ( J:171786 )

• increase in the amplitude of the acoustic startle response

• however, the habituation ratio is similar to controls

abnormal social investigation ( J:171786 )

• over multiple trials investigation time of an initially novel ovariectomized mouse declines much more slowly than in wild-type mice

nervous system

abnormal nervous system physiology ( J:171786 )

• decrease in glutamate induced serotonin release from hippocampal slices

abnormal hypothalamus secretion ( J:171786 )

• decrease in glutamate induced serotonin release from hypothalamic slices

• however, release in response to maximal stimulation with K⁺ is similar to wild-type controls

homeostasis/metabolism

increased serotonin level ( J:171786 )

• in the hypothalamus, hippocampus, and hindbrain

• however, levels of 5-HIAA, a serotonin metabolite, are similar to controls, suggesting impaired serotonin release

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
disease of mental health		DOID:150		J:171786