Analysis Tools
immune system
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
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• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
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• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
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• in an experimental autoimmune encephalomyelitis model
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• almost complete resistance
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
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growth/size/body
digestive/alimentary system
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• slight hyperplasia
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• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
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liver/biliary system
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• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
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respiratory system
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• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice
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hematopoietic system
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• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
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• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
|
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• in an experimental autoimmune encephalomyelitis model
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cellular
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• slight hyperplasia
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