Phenotypes Associated with This Genotype

Genotype
MGI:4868748

• Allelic Composition: Fto^tm1.3Pzg/Fto^tm1.3Pzg
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:166984 )

• only 50% of mice survive to postnatal day 10-14

growth/size/body

decreased lean body mass ( J:166984 )

decreased body weight ( J:166984 )

• after birth and at weaning

cachexia ( J:166984 )

• half of mice fed a high-fat diet become very lean due to illness

decreased body length ( J:166984 )

• regardless of diet

increased susceptibility to diet-induced obesity ( J:166984 )

• when fed a high-fat diet

postnatal growth retardation ( J:166984 )

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:166984 )

• when fed a high-fat diet

decreased circulating insulin-like growth factor I level ( J:166984 )

abnormal carbon dioxide production ( J:166984 )

• relative to lean mass, mice exhibit increased oxygen consumption and carbon dioxide production compared with wild-type mice

abnormal oxygen consumption ( J:166984 )

• relative to lean mass, mice exhibit increased oxygen consumption and carbon dioxide production compared with wild-type mice

integument

dermatitis ( J:166984 )

• in half of mice fed a high-fat diet

skeleton

decreased bone mineral density ( J:166984 )

• regardless of diet

adipose tissue

increased total body fat amount ( J:166984 )

• in female mice at 16 weeks

behavior/neurological

abnormal eating behavior ( J:166984 )

• when normalized to lean mass

immune system

dermatitis ( J:166984 )

• in half of mice fed a high-fat diet