Phenotypes Associated with This Genotype

Genotype
MGI:4840406

hm1

• Allelic Composition: Sh2d1b1/Sh2d1b2^tm1.1Cpt/Sh2d1b1/Sh2d1b2^tm1.1Cpt
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:166054 )

• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice

• NK cell RMAS/CD48+, P815/CD84+, or B16/CD84+ tumors cell killing is impaired in vivo compared with wild-type cells

• NK cell P815/CD48+ tumors cell killing is abolished in vivo compared with wild-type cells

• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice

• NK cells kill anti-CD84-coated P815 and B16 cells less efficiently killed compared to wild-type cells

• however, clearance of RMAS/CD48- tumor cells is normal and NK cells efficiently kill YB2/0, YAC-1, and CHO cells

decreased interferon-gamma secretion ( J:166054 )

• in NK cells stimulated by CD244 with anti-CD244 antibodies

• however, IFN-gamma production by NK cells stimulated by anti-Ly49D or anti-NKG2D stimulation

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:166054 )

• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice

• NK cell RMAS/CD48+, P815/CD84+, or B16/CD84+ tumors cell killing is impaired in vivo compared with wild-type cells

• NK cell P815/CD48+ tumors cell killing is abolished in vivo compared with wild-type cells

• NK cells are defective in anti-CD244 dependent killing of 51Cr-labeled P815 cells compared with wild-type mice

• NK cells kill anti-CD84-coated P815 and B16 cells less efficiently killed compared to wild-type cells

• however, clearance of RMAS/CD48- tumor cells is normal and NK cells efficiently kill YB2/0, YAC-1, and CHO cells