Phenotypes Associated with This Genotype

Genotype
MGI:4839903

• Allelic Composition: Tg(Myh6-Myh7)137Rbns/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart atrium morphology ( J:166125 )

• atrial weight is increased prior to and following isoproterenol treatment compared with similarly treated wild-type mice

increased heart left atrium size ( J:166125 )

• mild

abnormal heart left ventricle morphology ( J:166125 )

• 8 weeks after coronary ligation, mice exhibit increased left ventricle end-diastolic diameter compared with similarly treated wild-type mice

• 6 and 8 weeks after coronary ligation, mice exhibit increased left ventricle end-systolic diameter compared with similarly treated wild-type mice

• after swim training, left ventricle end-systolic free wall thickness is not increased compared to in similarly treated wild-type mice

increased heart left ventricle weight ( J:166125 )

• following coronary ligation

increased heart right ventricle weight ( J:166125 )

• after isoproterenol treatment compared with similarly treated wild-type mice

decreased cardiac muscle contractility ( J:166125 )

• following coronary ligation at 8 weeks

decreased left ventricle systolic pressure ( J:166125 )

• dobutamine-treated mice exhibit decreased left ventricular systolic peak pressure compared with similarly treated wild-type mice

abnormal response to cardiac infarction ( J:166125 )

• following coronary ligation mice exhibit increased left ventricle and lung weight, decreased fractional shortening, and increased left ventricle end-diastolic and -systolic diameter compared with similarly treated wild-type mice

decreased systemic arterial systolic blood pressure ( J:166125 )

• 24 hours and 2 weeks after isoproterenol treatment compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:166125 )

• following coronary ligation mice exhibit increased left ventricle and lung weight, decreased fractional shortening, and increased left ventricle end-diastolic and -systolic diameter compared with similarly treated wild-type mice

abnormal physiological response to xenobiotic ( J:166125 )

• dobutamine-treated mice exhibit decreased left ventricular systolic peak pressure compared with similarly treated wild-type mice

• after isoproterenol treatment, mice exhibit increased left and right ventricle weight, atrial weight, and decreased systolic blood pressure compared with similarly treated wild-type mice

muscle

decreased cardiac muscle contractility ( J:166125 )

• following coronary ligation at 8 weeks

respiratory system

increased lung weight ( J:166125 )

• following coronary ligation

growth/size/body

increased lung weight ( J:166125 )

• following coronary ligation