Analysis Tools
immune system
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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• in the periphery (lymph nodes and blood)
• however, thymic populations are normal
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• migration of T cells on Transwell membranes is reduced compared with wild-type cells
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment compared with wild-type cells
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• despite a reduction in number, the percentage of CD8+ T cells in the lymph nodes tends to increase compared to in wild-type mice
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• despite a reduction in number, the percentage of CD8+ T cells in the lymph nodes tends to increase compared to in wild-type mice
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hematopoietic system
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
|
|
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
|
|
• in the periphery (lymph nodes and blood)
• however, thymic populations are normal
|
|
• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• migration of T cells on Transwell membranes is reduced compared with wild-type cells
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment compared with wild-type cells
|
|
• despite a reduction in number, the percentage of CD8+ T cells in the lymph nodes tends to increase compared to in wild-type mice
|
cellular
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• the frequency of naive T cells in contact with high-endothelial venules is increased compared to in wild-type mice
• in adoptive transfer experiments, T cells exhibit shorter tracks, less displacement from their origin, reduced median speed, lower frequency of cells reaching peak instantaneous velocities, increased median turning angle, decreased average motility coefficient, and greater accumulation in lymph nodes due to impaired lymph node exit compared with wild-type cells
• naive T cells exhibit reduced Transwell chemotaxis in response to CCL21 compared with wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
|
|
• T cells exhibit a 2-fold greater adhesion to ICAM-1 under flow compared with similarly treated wild-type cells
• naive T cells exhibit inefficient crawling within a confined environment (8-4 um) compared with wild-type cells
• however, T cell crawling in a large width (12-20 um) lane is normal
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