Phenotypes Associated with This Genotype

Genotype
MGI:4820640

hm2

• Allelic Composition: Terc^tm1Rdp/Terc^tm1Rdp
• Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125218 )

• median survival is reduced in successive generations compared to in wild-type mice

digestive/alimentary system

increased enterocyte apoptosis ( J:125218 )

• regardless of generation

abnormal enterocyte proliferation ( J:125218 )

• intestinal cell proliferation is impaired compared to in wild-type mice

abnormal intestine morphology ( J:125218 )

• mice exhibit mild to severe intestinal atrophy unlike wild-type mice that worsens in successive generations

cellular

decreased telomere length ( J:125218 )

• telomeres become progressively shorter each generation unlike in wild-type mice

abnormal cell physiology ( J:125218 )

• mouse embryonic fibroblasts (MEFs) from third generation mice exhibit decreased immortalization ability under a 3T3 cell passage protocol compared with similarly treated wild-type cells

• sister chromatid exchange in MEFs is increased compared to in wild-type cells

increased enterocyte apoptosis ( J:125218 )

• regardless of generation

abnormal enterocyte proliferation ( J:125218 )

• intestinal cell proliferation is impaired compared to in wild-type mice

abnormal DNA repair ( J:125218 )

• cells from the small intestine exhibit an increase in gamma-H2AX foci, indicative of DNA damage, compared with cells from wild-type mice

chromosomal instability ( J:125218 )

• mouse embryonic fibroblasts (MEFs) exhibit in increase in microsatellite instability compared with wild-type cells

• end-to-end chromosome fusions in MEFs are increased compared to in wild-type cells

• MEFs from late generation mice exhibit an increase in chromosome breaks, fragments, bivalent recombination figures, and complex aberrations compared with wild-type cells

neoplasm

increased lymphoma incidence ( J:125218 )

• the incidence of lymphomas decreases in successive generation

homeostasis/metabolism

abnormal DNA repair ( J:125218 )

• cells from the small intestine exhibit an increase in gamma-H2AX foci, indicative of DNA damage, compared with cells from wild-type mice