Phenotypes Associated with This Genotype

Genotype
MGI:4819252

• Allelic Composition: Tg(Ela1-TAg)19Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:76995 )

• mice develop acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors in the pancreas

• all mice develop pancreatic exocrine carcinomas

increased insulinoma incidence ( J:76995 )

• in one mouse

increased pancreatic acinar cell carcinoma incidence ( J:76995 )

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:76995 )

pancreatic islet hyperplasia ( J:76995 )

• infrequent

increased pancreas tumor incidence ( J:76995 )

• mice develop acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors in the pancreas

• all mice develop pancreatic exocrine carcinomas

increased insulinoma incidence ( J:76995 )

• in one mouse

increased pancreatic acinar cell carcinoma incidence ( J:76995 )

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:76995 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:76995