About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4818410
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Gja5tm1Mchn/Gja5tm1Mchn
Tg(TIE2-lacZ)182Sato/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Gja5tm1Mchn mutation (1 available); any Gja5 mutation (19 available)
Tg(TIE2-lacZ)182Sato mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal mean arterial pressure, heart rate, and endothelium-dependent vasomotor responses to KCl and norepinephrine
• whether fed a high-fat or standard diet, mice exhibit increased lipid staining in the thoracoabdominal aortas compared with Apoetm1Unc homozygotes
• whether fed a high-fat or standard diet, mice exhibit accelerated atherosclerosis compared with Apoetm1Unc homozygotes

immune system
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes

respiratory system
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes

hematopoietic system
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory