Phenotypes Associated with This Genotype

Genotype
MGI:4460014

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Avil^tm2(cre)Fawa/Avil⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

gliosis ( J:160568 )

• at 9 months

increased neuron apoptosis ( J:160568 )

• at 9 months in the dorsal root ganglia

abnormal sensory neuron morphology ( J:160568 )

• at 9 months, neurons contain large inclusion bodies and numerous electron-dense organelles unlike in wild-type mice

neurodegeneration ( J:160568 )

• at 9 months, mice exhibit neurodegeneration of TrkA+, cRet+, TrkB+, and TrkC+ sensory neurons unlike in wild-type mice

behavior/neurological

limb grasping ( J:160568 )

• at 7 months

tremors ( J:160568 )

• between 7 and 9 months

bradykinesia ( J:160568 )

• at 7 months, mice exhibit reduced mobility compared with wild-type mice

• between 7 and 9 months, mice exhibit difficulties in movement unlike wild-type mice

limbs/digits/tail

curly tail ( J:160568 )

• between 7 and 9 months, mice develop stiffly twisted tails unlike wild-type mice

cellular

gliosis ( J:160568 )

• at 9 months

increased neuron apoptosis ( J:160568 )

• at 9 months in the dorsal root ganglia