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Phenotypes Associated with This Genotype
Genotype
MGI:4454427
Allelic
Composition
Large1myd-3J/Large1myd-3J
Genetic
Background
STOCK Large1myd-3J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Large1myd-3J mutation (1 available); any Large1 mutation (123 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Large1myd-3J/Large1myd-3J mice exhibit retinoschisis

vision/eye

muscle
N
• two assessed homozygotes, one 33 weeks old and the other 37 weeks old, do not show any abnormality in the heart muscle
• the outward phenotype associated with the muscle degeneration is usually not visible until 2 to 3 months of age, although phenotype at wean age can sometimes be found, and presents as an inability to splay the hind legs outward when lifted by the tail, then an increasingly swaying gait which progresses eventually to dragging of the hind legs

reproductive system
• no homozygous male has bred

behavior/neurological

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
muscular dystrophy-dystroglycanopathy type B6 DOID:0110637 OMIM:608840
J:160357


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory