Phenotypes Associated with This Genotype

Genotype
MGI:4452245

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-Csnk1d)#Mfla/0
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:158611 )

N • mice exhibit normal social and circadian behaviors

abnormal behavioral response to xenobiotic ( J:158611 )

• mice exhibit a 40 minute delay in D-amphetamine-induced hyperlocomotion compared with similarly treated wild-type mice

• D-amphetamine-treated mice exhibit a dose dependent suppression of vertical activity unlike similarly treated wild-type mice that exhibit an increase in vertical activity

decreased anxiety-related response ( J:158611 )

• in a dark-light choice test, mice exhibit increased rearing in the light compartment compared with wild-type mice

• in an elevated place maze, mice spend more time in the open arms than wild-type mice

• in a novelty suppressed feeding paradigm, mice exhibit shorter latency to feeding compared with wild-type mice

• however, mice exhibit normal anxiety-related behavior in an open field, forced swim, and tail suspension tests

abnormal locomotor activation ( J:158611 )

• mice exhibit a 40 minute delay in D-amphetamine-induced hyperlocomotion compared with similarly treated wild-type mice

• D-amphetamine-treated mice exhibit a dose dependent suppression of vertical activity unlike similarly treated wild-type mice that exhibit an increase in vertical activity

increased vertical activity ( J:158611 )

• in an open field test, mice exhibit increased vertical activity compared with wild-type mice

• increased activity begins at 6 weeks of age and persists at least until 16 months of age

• however, treatment with methylphenidate or haloperidol suppresses vertical activity

increased locomotor activity ( J:158611 )

• in an open field test, mice exhibit increased horizontal and vertical activity compared with wild-type mice

• increased activity begins at 6 weeks of age and persists at least until 16 months of age

• however, treatment with methylphenidate or haloperidol decreases activity levels

abnormal nest building behavior ( J:158611 )

• in an open field box, mice fail to build a nest unlike wild-type mice

nervous system

abnormal striatum morphology ( J:158611 )

• protein expression of dopamine receptors 1 and 2 and NMDA receptors are decreased in the striatum compared to in wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:158611 )

• MK801-treated mice exhibit a more rapid onset of increased horizontal activity and decreased vertical activity compared with similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:158611