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Phenotypes Associated with This Genotype
Genotype
MGI:4452098
cn62
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Rr94tm3.1Litt mutation (0 available); any Rr94 mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-positive T cell morphology ( J:158962 )
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice

hematopoietic system
abnormal double-positive T cell morphology ( J:158962 )
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory