Phenotypes Associated with This Genotype

Genotype
MGI:4452097

cn63

• Allelic Composition: Rr94^tm3.1Litt/Rr94^tm3.1Litt; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:158962 )

• mice exhibit the same phenotype as Cd4^tm3.2Litt homozygotes

decreased double-positive T cell number ( J:158962 )

• in the thymus

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice

hematopoietic system

abnormal T cell differentiation ( J:158962 )

• mice exhibit the same phenotype as Cd4^tm3.2Litt homozygotes

decreased double-positive T cell number ( J:158962 )

• in the thymus

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice