Phenotypes Associated with This Genotype

Genotype
MGI:4442842

• Allelic Composition: Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg; Tg(KRT14-cre)1Amc/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:158528 )

• most of the hair shafts are dysmorphic

• all of the layers of the shaft develop but the shafts are smaller and not as straight as in controls

integument

increased hair follicle apoptosis ( J:158528 )

• apoptotic cells are detected in the hair follicle at P1 and are even more numerous at P4, P6 and P8

• scattered apoptotic cells are detected in the interfollicular epidermis at P4, P6 and P8

decreased keratinocyte proliferation ( J:158528 )

• marked proliferation defect in culture cells

alopecia ( J:158528 )

• by P6 alopecia is virtually complete and persists throughout life

abnormal hair shaft morphology ( J:158528 )

underdeveloped hair follicles ( J:158528 )

• hair follicles are stunted in appearance

• hair follicles appear normal at E17.5 but stunting of hair follicles is easily apparent at all post-natal time points

abnormal hair follicle orientation ( J:158528 )

• most of the hair shafts are improperly angled and few penetrated the surface of the skin

decreased hair follicle number ( J:158528 )

• hair follicles have largely disappeared by P120

abnormal keratinocyte morphology ( J:158528 )

• keratinocytes in culture have a flattened morphology

cellular

increased hair follicle apoptosis ( J:158528 )

• apoptotic cells are detected in the hair follicle at P1 and are even more numerous at P4, P6 and P8

• scattered apoptotic cells are detected in the interfollicular epidermis at P4, P6 and P8

decreased keratinocyte proliferation ( J:158528 )

• marked proliferation defect in culture cells