Phenotypes Associated with This Genotype

Genotype
MGI:4442206

• Allelic Composition: Irf3^tm1Ttg/Irf3^tm1Ttg; Irf7^tm1Ttg/Irf7^tm1Ttg
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon-beta secretion ( J:158969 )

• F. tularensis live vaccine strain-, Sendai virus-, or synthetic B-form dsDNA (poly-dA:dT)-treated thioglycollate-elicited macrophages secrete less IFN-beta than similarly treated wild-type cells

• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells

decreased interleukin-1 beta secretion ( J:158969 )

• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B than similarly treated wild-type cells

• however, synthetic B-form dsDNA (poly-dA:dT)-treated mice produce normal amounts of IL1-beta

increased susceptibility to bacterial infection ( J:158969 )

• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B and IFN-beta than similarly treated wild-type cells

increased susceptibility to Herpesvirales infection ( J:158969 )

• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells

increased susceptibility to Paramyxoviridae infection ( J:158969 )

• Sendai virus-treated splenocytes secrete less IFN-beta than similarly treated wild-type cells