Analysis Tools
mortality/aging
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• mutant mice do not survive the postweaning period unless given highly hydrated food
• when fed a normal breeder diet, only 50% of mutants survive to P25 but none survive to P50
• when fed a semiliquid diet, 86% of mutantss survive to P25 and 69% survive to P50
• however, when the semiliquid feeding regimen is discontinued, mutant mice lose weight and eventually die within 2-3 days
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growth/size/body
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• mutant mice fed a normal breeder diet fail to thrive after weaning whereas those fed a semiliquid diet grow at a significantly reduced rate relative to wild-type controls
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behavior/neurological
digestive/alimentary system
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• at 21 days of age, mutant mice fed with a normal breeder diet display hemorrhages in the digestive tract
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• mutant mice fed a normal breeder diet display multiple chronic small intestine ulcers accompanied by intense hemorrhage
• however, no ulcers or intense hemorrhage are observed when mutant mice are fed a semiliquid diet
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• mutant mice fed with breeder diet display a severe villous atrophy in the duodenum
• lethal ulcerations appear to be prevented by a semiliquid diet
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• no food is ever found in mutant stomachs despite food ingestion
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• mutant mice fed a normal breeder diet display severe ulcerative jejunoileitis, characterized by multiple chronic small intestine ulcers and bleeding
• histological changes are pronounced in the duodenum and upper jejunum, less prominent in the lower jejunum, and nearly absent in the ileum
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immune system
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• mutant mice fed a normal breeder diet display severe ulcerative jejunoileitis, characterized by multiple chronic small intestine ulcers and bleeding
• histological changes are pronounced in the duodenum and upper jejunum, less prominent in the lower jejunum, and nearly absent in the ileum
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cardiovascular system
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• at 21 days of age, mutant mice fed with a normal breeder diet display hemorrhages in the digestive tract
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