Phenotypes Associated with This Genotype

Genotype
MGI:4437799

• Allelic Composition: Ahi1^tm1Jgg/Ahi1^tm1Jgg
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:158019 )

• mice die between birth and P10

vision/eye

vision/eye phenotype ( J:158019 )

N • photoreceptor ciliary axonemes are normal

abnormal retina apoptosis ( J:158019 )

• before 3 weeks of age

absent photoreceptor outer segment ( J:158019 )

• outer segments fail to form unlike in wild-type mice

retina photoreceptor degeneration ( J:158019 )

• at 1 month, mice exhibit rapid loss of outer nuclear (photoreceptor) layer unlike wild-type mice

thin retina outer nuclear layer ( J:158019 )

growth/size/body

decreased body size ( J:158019 )

decreased body weight ( J:158019 )

nervous system

absent photoreceptor outer segment ( J:158019 )

• outer segments fail to form unlike in wild-type mice

retina photoreceptor degeneration ( J:158019 )

• at 1 month, mice exhibit rapid loss of outer nuclear (photoreceptor) layer unlike wild-type mice

cellular

abnormal retina apoptosis ( J:158019 )

• before 3 weeks of age