Phenotypes Associated with This Genotype

Genotype
MGI:4431213

• Allelic Composition: Foxj3^Gt(XL913)Byg/Foxj3^Gt(XL913)Byg
• Genetic Background: either: 129P2/OlaHsd-Foxj3^Gt(XL913)Byg or B6.129P2-Foxj3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal extensor digitorum longus morphology ( J:157260 )

• a decrease in the number of oxidative Type I fibers and an increase in the numbers of Type IIa/b fibers in males

abnormal soleus morphology ( J:157260 )

• a decrease in the number of oxidative Type I fibers and an increase in the numbers of Type IIa/b fibers in males

abnormal skeletal muscle fiber type ratio ( J:157260 )

• a decrease in the number of oxidative Type I fibers and an increase in the numbers of Type IIa/b fibers in the soleus and extensor digitorum longus muscles in males

skeletal muscle necrosis ( J:157260 )

• observe persistent myonecrosis and widespread replacement of the myofibers with adipocytes following severe myonecrotic injury with cardiotoxin.

abnormal muscle physiology ( J:157260 )

• in skeletal muscle 5 days following cardiotoxin induced injury, cells exhibit an increased proliferative capacity, as measured by Ki67 expression

abnormal skeletal muscle satellite cell proliferation ( J:157260 )

• decrease in the G0/G1 phase and a significant increase in the G2/M phase as assayed by flow cytometry

impaired skeletal muscle contractility ( J:157260 )

• extensor digitorum longus muscles have decreased stress, with increased stimulation frequency

impaired skeletal muscle regeneration ( J:157260 )

• severe regenerative impairment that is evident at 2 and 3 weeks following delivery of cardiotoxin (severe myonecrotic injury)

cellular

abnormal skeletal muscle satellite cell proliferation ( J:157260 )

• decrease in the G0/G1 phase and a significant increase in the G2/M phase as assayed by flow cytometry

limbs/digits/tail

abnormal extensor digitorum longus morphology ( J:157260 )

• a decrease in the number of oxidative Type I fibers and an increase in the numbers of Type IIa/b fibers in males

abnormal soleus morphology ( J:157260 )

• a decrease in the number of oxidative Type I fibers and an increase in the numbers of Type IIa/b fibers in males