Phenotypes Associated with This Genotype

Genotype
MGI:4421853

ht7

• Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb^tm9Sor
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

abnormal retina vasculature morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

abnormal pericyte morphology ( J:86542 )

• 70-92% decrease in pericytes in the heart, kidney, and eye

• reduction in vascular smooth muscle cells/pericytes in the thoracic region of E14.5 mutants

abnormal heart morphology ( J:86542 )

• heart abnormalities

dilated heart atrium ( J:86542 )

increased heart ventricle size ( J:86542 )

cardiac fibrosis ( J:86542 )

eye hemorrhage ( J:86542 )

• sometimes exhibit hemorrhage in the eye

vision/eye

eye hemorrhage ( J:86542 )

• sometimes exhibit hemorrhage in the eye

abnormal eye morphology ( J:86542 )

• severe eye defects

abnormal retina vasculature morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

eye opacity ( J:86542 )