Phenotypes Associated with This Genotype

Genotype
MGI:4421709

• Allelic Composition: Tg(CAG-SYVN1)1Tn/?
• Genetic Background: D1.Cg-Tg(CAG-SYVN1)1Tn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

rheumatoid arthritis ( J:86009 )

• 10 of 33 mutants develop spontaneous arthropathy, with joint swelling at 20 weeks of age

• joints show severe synovial cell hyperplasia and bone destruction

skeleton

rheumatoid arthritis ( J:86009 )

• 10 of 33 mutants develop spontaneous arthropathy, with joint swelling at 20 weeks of age

• joints show severe synovial cell hyperplasia and bone destruction

cellular

decreased apoptosis ( J:86009 )

• slight but significant decrease in apoptosis of synovial cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
rheumatoid arthritis		DOID:7148	OMIM:180300	J:86009