Phenotypes Associated with This Genotype

Genotype
MGI:4421201

cx2

• Allelic Composition: Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast; Bmf^tm1Rjd/Bmf^tm1Rjd
• Genetic Background: B6.129S-Bcl2l11^tm1.1Ast Bmf^tm1Rjd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:153652 )

• reduced number of homozygous mice generated from intercross of the double heterozygous compared with the expected Mendelian inheritance

growth/size/body

decreased body weight ( J:153652 )

• decreased body weight at 6 weeks old

limbs/digits/tail

interdigital webbing ( J:153652 )

• persistence of interdigital tissue on both the front and rear paws

reproductive system

vagina atresia ( J:153652 )

♀ • imperforate vagina in female mice

hydrometrocolpos ( J:153652 )

♀ • hydrometrocolpos in female mice

immune system

decreased T cell apoptosis ( J:153652 )

• increased viability of CD4-positive and CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

increased thymocyte number ( J:153652 )

• increased numbers of CD4-positive, CD8-positive, and CD4/CD8 double-positive thymocytes

increased B cell number ( J:153652 )

• a large increase in the number of B cells in the spleen

increased CD4-positive, alpha-beta T cell number ( J:153652 )

• a large increase in the number of CD4-positive T cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:153652 )

• a large increase in the number of CD8-positive T cells in the spleen

increased splenocyte number ( J:153652 )

• a larger increased number of splenocytes (>5 fold)

hematopoietic system

decreased T cell apoptosis ( J:153652 )

• increased viability of CD4-positive and CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

increased thymocyte number ( J:153652 )

• increased numbers of CD4-positive, CD8-positive, and CD4/CD8 double-positive thymocytes

increased B cell number ( J:153652 )

• a large increase in the number of B cells in the spleen

increased CD4-positive, alpha-beta T cell number ( J:153652 )

• a large increase in the number of CD4-positive T cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:153652 )

• a large increase in the number of CD8-positive T cells in the spleen

increased splenocyte number ( J:153652 )

• a larger increased number of splenocytes (>5 fold)

cellular

decreased T cell apoptosis ( J:153652 )

• increased viability of CD4-positive and CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

endocrine/exocrine glands

increased thymocyte number ( J:153652 )

• increased numbers of CD4-positive, CD8-positive, and CD4/CD8 double-positive thymocytes