Phenotypes Associated with This Genotype

Genotype
MGI:4421198

hm1

• Allelic Composition: Bmf^tm1Rjd/Bmf^tm1Rjd
• Genetic Background: B6.129S6-Bmf^tm1Rjd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell apoptosis ( J:153652 )

• increased viability of CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

enlarged spleen ( J:153652 )

• moderately enlarged spleen

increased B cell number ( J:153652 )

• a moderate increase in the number of B cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:153652 )

• a moderate increase in the number of CD8-positive T cells in the spleen

increased splenocyte number ( J:153652 )

• increased splenocytes number (about 1.5 fold)

reproductive system

vagina atresia ( J:153652 )

♀ • imperforate vagina in 22% of female mice

hydrometrocolpos ( J:153652 )

♀ • hydrometrocolpos in 22% of female mice

immune system

decreased T cell apoptosis ( J:153652 )

• increased viability of CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

enlarged spleen ( J:153652 )

• moderately enlarged spleen

increased B cell number ( J:153652 )

• a moderate increase in the number of B cells in the spleen

increased CD8-positive, alpha-beta T cell number ( J:153652 )

• a moderate increase in the number of CD8-positive T cells in the spleen

increased splenocyte number ( J:153652 )

• increased splenocytes number (about 1.5 fold)

cellular

decreased T cell apoptosis ( J:153652 )

• increased viability of CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

growth/size/body

enlarged spleen ( J:153652 )

• moderately enlarged spleen