Analysis Tools
homeostasis/metabolism
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• mice treated with kainate acid exhibit decreased microglial accumulation and reduced neurodegeneration in the CA1 and CA3 pyramidal neurons compared with similarly treated wild-type mice
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• when fed a high fat diet, mice exhibit a mildly enhanced weight gain compared with similarly treated wild-type mice
• at 18 to 34 weeks, mice fed a high fat diet exhibit a 13% increase in body weight compared with similarly treated wild-type mice
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• when fed a high fat diet
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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• mild in fasting mice regardless of diet
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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• when fed a high fat diet
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• during hyperinsulinemic-euglycemic clamp analysis, mice fed a high fat diet exhibit a 3-fold increase in basal and clamp hepatic glucose production compared with similarly treated wild-type mice
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• at 14 and 27 weeks regardless of diet
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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• regardless of diet
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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behavior/neurological
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• mice fail to exhibit nociceptive hypersensitivity to mechanical, heat, and cold stimuli induced by injection of an adenovirus overexpressing Gm34583 unlike control mice
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adipose tissue
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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• when fed a high fat diet, macrophage infiltration of the epididymal fat pad is reduced compared to in similarly treated wild-type mice
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• mice fed a high fat diet exhibit a mild increase in macrophage infiltration of adipose tissue compared with similarly treated wild-type mice
• however, macrophage numbers in subcutaneous fat when fed a standard diet is normal
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• when fed a high fat diet
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• 15% in mice fed a high fat diet compared with similarly treated wild-type mice
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liver/biliary system
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• when mice are fed a high fat diet compared with similarly treated wild-type mice
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growth/size/body
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• slightly when mice are fed a standard diet
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• when fed a high fat diet, mice exhibit a mildly enhanced weight gain compared with similarly treated wild-type mice
• at 18 to 34 weeks, mice fed a high fat diet exhibit a 13% increase in body weight compared with similarly treated wild-type mice
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nervous system
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• mice treated with kainate acid exhibit decreased microglial accumulation compared with similarly treated wild-type mice
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• small, medium, and large neurons from mice injected with an adenovirus overexpressing Gm34583 fail to exhibit increases in the number of action potentials evoked by injected currents unlike control neurons
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• small, medium, and large neurons from mice injected with an adenovirus overexpressing Gm34583 fail to exhibit depolarization unlike control neurons
• small and medium, but not large, neurons from mice injected with an adenovirus overexpressing Gm34583 fail to exhibit an increase in the frequency of spontaneous activity unlike control neurons
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• mice treated with kainate acid exhibit decreased microglial accumulation and reduced neurodegeneration in the CA1 and CA3 pyramidal neurons compared with similarly treated wild-type mice
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immune system
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• mice treated with kainate acid exhibit decreased microglial accumulation compared with similarly treated wild-type mice
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cellular
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• mice treated with kainate acid exhibit decreased microglial accumulation and reduced neurodegeneration in the CA1 and CA3 pyramidal neurons compared with similarly treated wild-type mice
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• mice treated with kainate acid exhibit decreased microglial accumulation compared with similarly treated wild-type mice
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hematopoietic system
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• mice treated with kainate acid exhibit decreased microglial accumulation compared with similarly treated wild-type mice
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