Phenotypes Associated with This Genotype

Genotype
MGI:4412290

• Allelic Composition: Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺; Tmem163^{Tg(ACTB-cre)2Mrt}/0; Tg(Fev-flpe)1Dym/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart rate ( J:231745 )

• heart rate is slower by 6-10% at P5 and P8

behavior/neurological

enhanced contextual conditioning behavior ( J:154944 )

increased exploration in new environment ( J:154944 )

decreased anxiety-related response ( J:154944 )

• mice are less averse to open, brightly lit spaces compared with wild-type mice

• female mice exhibit decreased anxiety-related behaviors in open field, zero-maze, and light-dark tests compared with wild-type mice

growth/size/body

decreased body size ( J:231745 )

• pups are smaller than controls by 15-21% at P5 and P8

nervous system

abnormal axon morphology ( J:154944 )

• 5HT+ axon varicosities are enlarged compared to in wild-type mice

increased prepulse inhibition ( J:154944 )

homeostasis/metabolism

abnormal oxygen consumption ( J:231745 )

• oxygen consumption is slightly but significantly lower at P5 and higher at P12

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:231745 )

• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12; deaths occur during the anoxic challenge

respiratory system

increased tidal volume ( J:231745 )

• tidal volume is increased by 18-34% at P8 and P12

abnormal breathing pattern ( J:231745 )

• increase in baseline breathing variability at P5

• autoresuscitation is less effective compared to controls following repeated episodic exposure to anoxia and results in increased mortality at P5 and P8, with only 16% of pups surviving to the endpoint at P12

• pups exposed to anoxia that die at P5 take 4 times longer to initiate gasping and 4 times longer to recover heart rate and eupneic breathing to 90% of baseline

hypopnea ( J:231745 )

• pups have slower breathing than controls by 14% at P5 and P8

increased pulmonary ventilation ( J:231745 )

• 28% larger minute ventilation at P12

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sudden infant death syndrome		DOID:9007	OMIM:272120	J:231745