Phenotypes Associated with This Genotype

Genotype
MGI:4412003

• Allelic Composition: Tlr4^Lps-d/Tlr4^Lps-d
• Genetic Background: B6.C3-Tlr4^Lps-d

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal artery morphology ( J:101995 )

• no increase in thickness of external elastic lamina after treatment with lipopolysaccharide

• no increase in external elastic lamina of contralateral carlotid arteries after 28 days of carotid artery ligation

• no increase in area of the media

atherosclerotic lesions ( J:101995 )

• larger plaques made up of smooth muscle and foam cells when treated with lipopolysaccharide and on a high fat diet

abnormal vascular wound healing ( J:101995 )

• increased neointimal formation but not to the extent seen in controls after lipopolysaccharide treatment

• no correlation between external elastic lamina area and neointimal area as is seen in controls

homeostasis/metabolism

abnormal vascular wound healing ( J:101995 )

• increased neointimal formation but not to the extent seen in controls after lipopolysaccharide treatment

• no correlation between external elastic lamina area and neointimal area as is seen in controls