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Phenotypes Associated with This Genotype
Genotype
MGI:4398676
Allelic
Composition
Ddit3tm1Dron/Ddit3tm1Dron
Genetic
Background
B6.129-Ddit3tm1Dron
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3tm1Dron mutation (1 available); any Ddit3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type

cellular
• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

hematopoietic system
• under cholesterol loading conditions, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages
• macrophages treated with excess lipoprotein-cholesterol or tunicamycin fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory