Phenotypes Associated with This Genotype

Genotype
MGI:4367909

• Allelic Composition: Dp(17Abcg1-Cbs)1Yah/0
• Genetic Background: B6.129P2-Dp(17Abcg1-Cbs1)1Yah

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:154298 )

N • mice exhibit normal motor coordination, motor learning, balance, muscular tonus, and anxiety-related behavior

abnormal short-term object recognition memory ( J:154298 )

• in a second session, mice spend more time exploring a familiar object and less time exploring a novel object compared with wild-type mice

• however, novel object exploration during the initial session is normal

impaired short-term object recognition memory ( J:154298 )

• in a second session 24 hours after the first, mice fail habituate and exhibit a 21% increase in distance traveled compared with wild-type mice

• however, activity during the initial session in an open field is normal

abnormal spatial learning ( J:154298 )

• during the learning phase of a Morris water maze, mice exhibit enhanced spatial learning compared with wild-type mice

abnormal short-term spatial reference memory ( J:154298 )

• mice exhibit reduced spontaneous alternation in a Y-maze test compared with wild-type mice

increased vertical activity ( J:154298 )

• in a second session 24 hours after the first, mice fail habituate and exhibit a 44% increase in rearing compared with wild-type mice

• however, activity during the initial session in an open field is normal

nervous system

enhanced long-term potentiation ( J:154298 )

• mice exhibit larger and longer-lasting long term potentiation compared with wild-type mice

homeostasis/metabolism

decreased circulating homocysteine level ( J:154298 )

• homocysteine levels are decreased compared to in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:154298